FIG. 4.

Effects of immunosuppressors on OdDHL-induced inhibition of secretory responses to ATP by CF-KM4 cells. Confluent CF-KM4 cells were exposed for 24 h to 1 nM OdDHL with or without 0.1 μM dexamethasone or 10 μM indomethacin, NDGA, or ibuprofen. The cells were then washed and exposed for 30 min to 100 μM ATP. The SLPI secretion was determined as described for Fig. 1. Values are given as means ± SDs for three experiments (n = 9). Where no agent was added, only the vehicle was added to the cells. Statistical significance is indicated as described for Fig. 1. Note that only NDGA and ibuprofen prevented the inhibition of stimulation of SLPI secretion by ATP in CF-KM4 cells.