FIG. 5.

Dose dependency of the prevention by ibuprofen of OdDHL inhibition of ATP-induced stimulation of SLPI secretion by CF-KM4 cells. Cells grown to confluency were exposed to 1 nM OdDHL and to increasing concentrations of ibuprofen for 24 h. The cells were then washed and exposed for 30 min to 100 μM ATP. For each concentration of ibuprofen tested, secretion of SLPI in response to 100 μM ATP is presented and compared to the control value (Ctrl). Means and SDs are shown (n = 12). Statistical significance is indicated as described for Fig. 1.