Table 2.
Univariate linear regression models examining association between mtDNA-CN and clinical risk factors.
| Outcome: MtDNA–CN | β | p –value | 95% CI |
|---|---|---|---|
| Age at baseline (years) | −0.5 | 0.01 | −0.9; −0.1 |
| BMI (kg/m2) | −0.3 | 0.03 | −0.5; −0.03 |
| Smoker (yes or former vs. no) | −8.0 | < 0.0001 | −0.1; −5.4 |
| Alcohol consumption (grams per day) | 2.5 | 0.006 | 0.7; 4.2 |
| Education (< = 9 years vs. > 9 years) | −3.4 | 0.002 | −5.5; −1.3 |
| Activity at home (low vs. medium or high)a | −8.3 | 0.001 | −13; −3.4 |
| Systolic blood pressure (mmHg) | −0.1 | 0.02 | −0.1; −0.01 |
| Diastolic blood pressure (mmHg) | −0.04 | 0.52 | −0.2; 0.1 |
| Total cholesterol (mg/dL) | 0.7 | 0.18 | −0.3; 1.6 |
| Triglycerides (mg/dL) | −1.8 | 0.001 | −2.9; −0.7 |
| HDL (mg/dL) | 4.8 | < 0.0001 | 2.5; 7.1 |
| LDL (mg/dL) | 0.8 | 0.14 | −0.3; 2.0 |
| Prevalent T2D (yes vs. no) | −7.2 | 0.004 | −12; −2.3 |
| Prevalent cancer (yes vs. no) | 2.6 | 0.28 | −2.1; 7.2 |
| Prevalent MI (yes vs. no) | −3.2 | 0.71 | −19; 13 |
a
Low = hardly anything at all or mostly sedentary, medium or high = lighter physical exertion, strenuous exercise 1–2 h/week, strenuous exercise at least 3 h/week or hard regular exercise.