Table 3.

Cox regression models examining effect of mtDNA-CN and other risk factors on risk for incident heart failure.

	Univariate			Adjusted a
Outcome: time to heart failure	HR	p -value	95% CI	HR	p -value	95% CI
MtDNA-CN (decrease, std)b	1.44	< 0.0001	1.20; 1.74	1.34	0.003	1.11; 1.63
MtDNA-CN quartilesc
Q3 vs. Q4	1.44	0.18	0.84; 2.47	1.18	0.56	0.68; 2.04
Q2 vs. Q4	1.91	0.01	1.14; 3.20	1.63	0.07	0.96; 2.74
Q1 vs. Q4	2.60	0.001	1.47; 4.58	2.04	0.02	1.14; 3.63
Age at baseline (years)	1.11	0.001	1.04; 1.19
BMI (kg/m2)	1.05	0.02	1.01; 1.09
Smoker (yes or former vs. no)	1.55	0.04	1.03; 2.32
Alcohol consumption (grams per day)	0.89	0.46	0.66; 1.21
Education (< = 9 years vs. > 9 years)	1.90	0.001	1.28; 2.81
Activity at home (low vs. medium or high)	1.67	0.14	0.85; 3.30
Systolic blood pressure (mmHg)	1.02	< 0.0001	1.01; 1.03
Diastolic blood pressure (mmHg)	1.03	0.004	1.01; 105
Total cholesterol (mg/dL)	0.90	0.22	0.75; 1.07
Triglycerides (mg/dL)	1.22	0.01	1.05; 1.43
HDL (mg/dL)	0.63	0.02	0.42; 0.94
LDL (mg/dL)	1.02	0.87	0.84; 1.24
Prevalent T2D (yes vs. no)	2.13	0.02	1.14; 3.96
Prevalent cancer (yes vs. no)	1.96	0.03	1.05; 3.65
Prevalent MI (yes vs. no)	11.2	< 0.0001	4.13; 30.3

^aAdjusted for age, bmi, smoking, education, systolic, triglycerides, HDL and prevalent T2D.

^bMtDNA-CN has been reversed and standardized (HR for a one standard deviation decrease in mtDNA-CN).

^cQ₁ = 32.4–88, Q₂ = 89–110, Q₃ = 111–130, Q₄ = 131–226.