Table 4.

Effect of mtDNA on heart failure using competing-risks regression model by a subdistribution hazard approach (fine and gray).

	Univariate			Adjusted a
Outcome: time to heart failure	SHRb	p -value	95% CI	SHR	p -value	95% CI
MtDNA (decrease, std)c	1.40	0.008	1.09; 1.80	1.32	0.03	1.03; 1.71
MtDNA quartilesd
Q3 vs. Q4	1.23	0.54	0.64; 2.34	1.04	0.91	0.54; 2.02
Q2 vs. Q4	1.56	0.16	0.84; 2.91	1.39	0.30	0.74; 2.61
Q1 vs. Q4	2.34	0.01	1.19; 4.58	1.88	0.07	0.96; 3.71

^aAdjusted for age, bmi, smoking, education, systolic, triglycerides and hdl.

^bSubdistributional hazard ratio where cancer, MI and death are considered competing events.

^cMtDNA has been reversed and standardized (HR for a one standard deviation decrease in mtDNA).

^dQ₁ = 32.4–88, Q₂ = 89–110, Q₃ = 111–130, Q₄ = 131–226.