Table 5.
Cox regression models examining effect of mtDNA-CN on overall mortality and mortality due to heart failure.
| Univariate | Adjusted a | |||||
|---|---|---|---|---|---|---|
| Outcome: time to death (any)b | HR | p -value | 95% CI | HR | p -value | 95% CI |
| MtDNA-CN (decrease, std)c | 1.27 | 0.001 | 1.10; 1.46 | 1.20 | 0.02 | 1.03; 1.39 |
| MtDNA-CN quartilesd | ||||||
| Q3 vs. Q4 | 2.02 | 0.001 | 1.35; 3.03 | 1.87 | 0.004 | 1.23; 2.85 |
| Q2 vs. Q4 | 1.77 | 0.007 | 1.16; 2.68 | 1.50 | 0.07 | 0.97; 2.33 |
| Q1 vs. Q4 | 2.22 | 0.001 | 1.39; 3.55 | 1.87 | 0.01 | 1.14; 3.05 |
| Outcome: time to death due to heart failuree | ||||||
| MtDNA-CN (decrease, std) | 1.93 | 0.04 | 1.04; 3.60 | 1.57 | 0.15 | 0.85; 2.90 |
a
Adjusted for age, smoking, alcohol consumption, education, activity and HDL.
b
Number of deaths = 195.
c
MtDNA-CN has been reversed and standardized (HR for a one standard deviation decrease in mtDNA-CN).
d
Q1 = 32.4–88, Q2 = 89–110, Q3 = 111–130, Q4 = 131–226.
e
Number of deaths due to heart failure = 11 (found in death register, all causes ICD10 = I50 or I110).