Table 3.

HRV in relation to different CSVD markers according to diabetic status stratification.

	Univariate analyses		Mulitivariate analyses
Variables			Model 1		Model 2
	OR (95% CI)	P-value	aOR (95% CI)	P-value	aOR (95% CI)	P-value
All subjects
Severe WMH	0.991 (0.984–0.998)	0.013	0.981 (0.944–0.989)	0.173	0.942 (0.932–0.969)	0.214
Lacunes	0.992 (0.986–0.999)	0.025	0.983 (0.966–0.979)	0.189	0.953 (0.934–0.976)	0.343
EPVS	0.985 (0.978–0.992)	<0.001	0.979 (0.962–0.989)	0.003	0.977 (0.950–0.989)	0.010
CMBs	0.989 (0.982–0.997)	0.004	0.968 (0.976–0.983)	0.082	0.967 (0.961–0.982)	0.132
Diabetic patients
Severe WMH	0.976 (0.959–0.993)	0.005	0.988 (0.976–0.998)	0.005	0.955 (0.944–0.993)	0.015
Lacunes	0.970 (0.953–0.988)	0.001	0.965 (0.945–0.987)	0.014	0.966 (0.952–0.996)	0.021
EPVS	0.962 (0.942–0.983)	<0.001	0.976 (0.964–0.982)	0.006	0.962 (0.946–0.986)	0.013
CMBs	0.971 (0.954–0.988)	0.001	0.979 (0.958–0.987)	0.008	0.967 (0.950–0.987)	0.011
Non-diabetic patients
Severe WMH	0.994 (0.986–1.002)	0.124	0.973 (0.967–0.992)	0.381	0.963 (0.955–0.984)	0.435
Lacunes	0.998 (0.991–1.006)	0.608	0.975 (0.969–0.995)	0.645	0.962 (0.946–0.981)	0.638
EPVS	0.990 (0.983–0.998)	0.012	0.968 (0.953–0.980)	0.176	0.964 (0.956–0.987)	0.425
CMBs	0.995 (0.987–1.004)	0.270	0.970 (0.978–0.999)	0.462	0.963 (0.957–0.989)	0.466

Model 1: adjusted for age and sex.

Model 2: adjusted for age, sex, current smoking, alcohol use, history of hypertension, using of ß-receptor blocker, using of lipid lowering drugs, SBP, HbA1c, LDL, and HR levels.

WMH, white matter hyperintensity; EPVS, enlarged perivascular spaces; CMBs, cerebral microbleeds; SBP, systolic blood pressure; HAb1c, hemoglobin A1c; LDL, low-density lipoprotein.