Table 1.

Patient characteristics.

Patient	Age	Gender	Histology	Brain metastasis	Extracranial lesions	EGFR mutation	Concomitant mutations	Neurological symptoms
1	76	Female	Adenocarcinoma	Multiple, LM	Lung, bone	EGFR L858R		Dizziness, headache nausea and vomiting
2	50	Female	Adenocarcinoma	Multiple, LM	Lung, liver, bone	EGFR 19del	CDKN2A, TP53, PTEN	Dizziness, headache gait disorder, vomiting
3	54	Female	Adenocarcinoma	LM		EGFR 19del	CDK4	Dizziness, headache
4	59	Male	Adenocarcinoma	Multiple, LM	Lung, bone	EGFR 19del		Dizziness, headache, cognitive impairment
5	52	Female	Adenocarcinoma	LM	Lung, bone	EGFR T790M		Dizziness, headache