Table 3.

Differences in the incidence of AEs with PD-1 vs PD-L1 inhibitors combined with TRT.

	PD-1 Incidence (%) (95%CI)	PD-L1 Incidence (%) (95%CI)	p value
All-grade AEs	93.14 (64.91-99.01)	81.74 (56.85-93.83)	0.35
Esophagitis	49.68 (33.46-65.97)	60.00 (44.35-73.85)	0.38
Anorexia	45.00 (25.32-66.38)	12.09 (1.01-64.91)	0.20
Fatigue	29.93 (17.08-46.98)	40.24 (3.38-92.83)	0.77
Diarrhea	15.73 (12.97-18.95)	13.93 (8.84-21.28)	0.62
Elevated ALT	15.56 (9.43-24.57)	14.29 (8.09-23.99)	0.99
Pneumonitis	15.20 (9.25-23.95)	4.88 (1.84-12.29)	0.03
Nausea	14.90 (7.78-26.65)	9.50 (0.55-66.74)	0.74
Pruritus	9.93 (7.70-12.71)	16.22 (7.47-31.69)	0.23
Skin rash	9.89 (7.65-12.69)	10.66 (6.29-17.49)	0.80
Hypothyroidism	9.59 (7.42-12.31)	12.97 (1.38-61.30)	0.78
Elevated AST	7.31 (5.48-9.68)	14.29 (8.09-23.99)	0.82
Hyperthyroidism	6.63 (4.82-9.06)	8.54 (4.12-16.84)	0.53
Arthralgia	5.64 (3.97-7.95)	9.37 (3.76-21.49)	0.30
High-grade AEs	16.49 (5.87-38.48)	22.06 (8.72-45.63)	0.66
Leukopenia	6.25 (2.83-13.22)	59.09 (38.17-77.16)	0.00
Elevated ALT	1.61 (0.23-10.57)	1.30 (0.18-8.64)	0.88
Skin rash	0.73 (0.28-1.94)	1.64 (0.41-6.32	0.35
Pneumonitis	0.62 (0.23-1.65)	2.44 (0.61-9.23)	0.11
Elevated AST	0.52 (0.17-1.61)	2.83 (0.27-23.65)	0.20
Diarrhea	0.35 (0.09-1.39)	0.82 (0.12-5.58)	0.49
Grade 5 AEs	0.23 (0.01-4.05)	0.69 (0.10-4.76)	0.53
Arthralgia	0.19 (0.00-0.74)	0.00 (0.00-1.17)	0.46
Fatigue	0.17 (0.02-1.16)	1.64 (0.41-6.32)	0.06

The bold values mean that there are significant statistical differences in subgroup analysis of these AEs.