Table 5.

Differences in the incidence of AEs with ESCC vs EAC groups.

	ESCC Incidence (%) (95%CI)	EAC (at least 70%) Incidence (%) (95%CI)	p value
All-grade AEs	92.96 (61.56-99.09)	83.31 (66.21-92.71)	0.41
Esophagitis	49.68 (33.46-65.97)	60.00 (44.35-73.85)	0.38
Fatigue	25.16 (10.22-49.83)	51.80 (9.65-91.54)	0.37
Hypothyroidism	22.55 (9.34-45.15)	8.96 (6.88-11.60)	0.049
Elevated AST	20.26 (10.22-36.19)	8.84 (4.53-16.53)	0.08
Skin rash	15.25 (8.13-26.79)	9.52 (7.43-12.12)	0.17
Elevated ALT	14.19 (6.89-26.98)	14.29 (8.09-23.99)	0.99
Pneumonitis	12.89 (7.70-20.80)	2.70 (0.38-16.85)	0.11
Anorexia	12.23 (0.95-66.87)	42.50 (28.31-58.04)	0.23
Nausea	10.05 (2.70-31.04)	20.94 (7.39-46.76)	0.36
Pruritus	9.09 (2.28-29.96)	10.37 (8.12-13.15)	0.85
Hyperthyroidism	8.93 (3.77-19.72)	6.68 (4.90-9.05)	0.53
Arthralgia	4.44 (1.11-16.11)	8.01 (3.57-16.96)	0.46
Diarrhea	1.12 (0.02-34.05)	17.24 (14.44-20.45)	0.14
High-grade AEs	14.41 (4.62-36.91)	24.75 (13.43-41.09)	0.37
Leukopenia	6.25 (2.83-13.22)	59.09 (38.17-77.16)	0.00
Elevated AST	2.38 (0.33-15.06)	0.99 (0.12-7.64)	0.55
Fatigue	1.68 (0.42-6.47)	0.12 (0.00-7.80)	0.24
Elevated ALT	1.61 (0.23-10.57)	1.30 (0.18-8.64)	0.88
Grade 5 AEs	0.98 (0.25-3.83)	0.10 (0.00-6.72)	0.33
Pneumonitis	0.64 (0.09-4.41)	0.88 (0.37-2.09)	0.77

The bold values mean that there are significant statistical differences in subgroup analysis of these AEs.