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. 2022 Nov 10;9:1038114. doi: 10.3389/fcvm.2022.1038114

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Copyright © 2022 MacDonnell, Megna, Ruan, Zhu, Halasz, Jasewicz, Powers, E, del Pilar Molina-Portela, Jin, Zhang, Torello, Feric, Graziano, Shekhar, Dunn, Glass and Morton.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activin A induces SMAD3 phosphorylation and downstream signaling in hiPSC-CMs. (A) Automated western blot data for the effect of Activin A plus anti–Activin A antibody or an isotype control on SMAD2/3 phosphorylation. (B) RNA sequencing data for expression of FSTL3, and SERPINE1 (PAI1) expression following exposure to 1 nM Activin A. One-way ANOVA was used to determine significance. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. ActA, Activin A; hiPSC-CM, human-induced pluripotent stem cell-derived cardiomyocyte; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; TPM, transcripts per million.