Table 1.

Patient and tumour characteristics

	MPM (n=11 539)	MPeM (n=629)	Total (N=12 168)	P value
Age, median (IQR)	71 (64–77)	69 (61–76)	71 (64–77)	0.004
Male, n (%)	10 085 (87.4)	458 (72.3)	10 543 (86.6)	<0.001
Histology, n (%)*
Epithelioid	6061 (76.2)	368 (88)	6429 (76.8)	<0.001*
Sarcomatoid	1149 (14.5)	18 (4.3)	1167 (13.9)
Biphasic	739 (9.3)	32 (7.7)	771 (9.2)
Unknown	3590	211	3801
Side, n (%)*
Left	4499 (40.4)	–	–
Right	6631 (59.6)	–	–
Unknown	409	–	–
Stage (TNM), n (%)*
I	2840 (37.2)	–	–
II	918 (12)	–	–
III	1971 (25.8)	–	–
IV	1897 (24.9)	–	–
Unknown	3913	–	–
Stage (EOD), n (%)*
1. In situ	–	0	–
2. Local disease	–	190 (40.8)	–
3. Contiguous/invasive	–	123 (26.4)	–
4. Regional lymph nodes	–	22 (4.7)	–
5. Regional progression	–	12 (2.6)	–
6. Distant progression	–	119 (25.5)	–
Unknown	–	163	–
Metastases, n (%)†	610 (10.6)	54 (18.6)	664 (11)	<0.001
Multiple metastatic sites	149 (2.6)	11 (3.8)	160 (2.6)	0.021
Most common metastatic sites, n (%)†
Lung	163 (2.8)	7 (2.4)	170 (2.8)
Lymph node	159 (2.8)	11 (3.8)	170 (2.8)
Bone	135 (2.3)	–	135 (2.2)
Liver	73 (1.3)	13 (4.5)	86 (1.4)
Peritoneum	79 (1.4)	5 (1.7)	84 (1.4)
Soft tissue	59 (1)	3 (1)	62 (1)
Adrenal glands	52 (0.9)	1 (0.3)	53 (0.9)
Pleura	12 (0.2)	15 (5.2)	27 (0.4)
Cutaneous	12 (0.2)	–	12 (0.2)
Brain	15 (0.3)	–	15 (0.2)

*Percentage and p value based on known cases.

†Metastases were registered nationwide from 2008 onwards; percentages based on 6038 cases (MPM n=5757, MPeM n=291).

EOD, Extent of Disease classification; MPeM, malignant peritoneal mesothelioma; MPM, malignant pleural mesothelioma; TNM, tumour, node, metastases classification.