TABLE 2.

Univariate model analysis of biomarkers in SAND cohort saliva.

Biomarker	CN vs. MCI	CN vs. AD	MCI vs. AD	CN vs. MCI/AD
Total protein (μg/mL)†	<0.0001	0.02	0.1	<0.0001
CST-C (μg/mL)†	0.02	0.26	0.01	0.50
CST-C/total protein ratio†	0.07	0.002	0.28	0.0008
IL-1RN (μg/mL)†	0.01	0.63	0.02	0.32
IL-1RN/total protein ratio†	0.30	0.01	0.17	0.03
SFN (μg/mL)†	0.03	0.55	0.03	0.48
SFN/total protein ratio†	0.10	0.04	0.67	0.02
MMP-9 (μg/mL)†	0.04	0.0002	0.50	0.0003
MMP-9/total protein ratio†	0.44	0.002	0.11	0.02
Hp (μg/mL)†	0.003	0.02	0.51	0.0007
Hp/total protein ratio†	0.21	0.08	0.41	0.06

^†Unadjusted p-values shown from log transformed data of absolute concentrations and their ratio to total protein.

AD, Alzheimer’s disease; CN, Cognitively Normal; CST-C, Cystatin-C; Hp, Haptoglobin; IL-1RN, Interleukin-1 receptor antagonist protein; Matrix metalloproteinase 9, MMP-9; MCI, Mild cognitive impairment; SFN, Stratifin; vs., versus.