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. 2022 Nov 10;12:1000146. doi: 10.3389/fonc.2022.1000146

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Copyright © 2022 Li, Meng, Xue, Teng, Chen, Zhang, Xu, Wang, Yu, Ou, Wu and Jia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The comparisons of somatic mutation characteristics and signatures among colorectal cancer patients with different stages. (A) The bar plots comparing gene alteration rates in early- (Stage 0~II, N=62) and late-stage patients (Stage III~IV, N=71). (B) Forest plot of somatic mutation rates of stage III colorectal cancer patients with metastatic disease (T3N0, N=34) compared to patients without metastatic disease (T3NX, N=38). (C) The bar plots comparing somatic mutation signatures between patients with metastatic disease (T3N0, N=34) and patients without metastatic disease (T3NX, N=38). *p < 0.05.