Table 1.
Patient characteristics and salivary autoantibody levels
| Overall | High-risk | Low-risk | p-value | |
|---|---|---|---|---|
| No. of cases (%) | 337 | 190 (56.4) | 147 (43.6) | – |
| Sex, male, n (%) | 331 (98.2) | 188 (98.9) | 143 (97.3) | 0.41a |
| Age, range | 31–82 | 32–82 | 31–78 | 0.003b |
| Years, median (IQR) | 50.4 (17) | 51.8 (15) | 49.2 (19) | |
| Smoking, n (%) | 306 (90.8) | 176 (92.6) | 130 (88.4) | 0.258c |
| Alcohol consumption, n (%) | 118 (35.0) | 81 (42.6) | 37 (25.2) | 0.001c |
| Betel nut chewing, n (%) | 271 (80.4) | 175 (92.1) | 96 (65.3) | < 0.001c |
| Autoantibodies, MFI, median (IQR) | ||||
| Anti-ANXA2 | 2727.2 (2611.4) | 2791.8 (3079.5) | 2600.1 (2244.6) | 0.253b |
| Anti-CA2 | 1191.2 (1232.8) | 1446.0 (1509.2) | 1020.0 (947.3) | < 0.001b |
| Anti-HSPA5 | 607.8 (722.8) | 757.5 (892.1) | 457.1 (484.0) | < 0.001b |
| Anti-ISG15 | 1273.7 (1299.0) | 1506.0 (1635.8) | 1021.4 (1004.4) | < 0.001b |
| Anti-KNG1 | 4176.5 (4720.2) | 4814.0 (6782.6) | 3379.6 (2981.0) | < 0.001b |
| Anti-MMP1 | 1426.3 (1214.5) | 1647.8 (1523.4) | 1239.3 (953.8) | < 0.001b |
| Anti-MMP3 | 3907.2 (548.4) | 4018.6 (777.1) | 3828.9 (405.2) | < 0.001b |
| Anti-p53 | 1616.7 (1782.1) | 1814.1 (2432.3) | 1485.1 (1437.4) | 0.003b |
| Anti-PRDX2 | 1038.0 (1286.3) | 1336.4 (1525.1) | 813.0 (865.5) | < 0.001b |
| Anti-SPARC | 707.0 (724.8) | 833.9 (956.5) | 555.2 (507.2) | < 0.001b |
IQR interquartile range, MFI median fluorescence intensity
p-values of high-risk and low-risk groups were compared
aFisher’s exact test
bMann–Whitney U test
cChi-square test