Table 4.
Co-occurrence of non-headache symptoms during paired migraine phases
| Subject-reported symptoms | Migraine phases | Percentage agreement (%) | k value | p value* | C.I. 95% |
|---|---|---|---|---|---|
| Irritability | Prodrome - Headache | 52 | 0.128 | 0.020 | 0.024–0.0231 |
| Prodrome - Postdrome | 60 | 0.162 | 0.005 | 0.037–0.280 | |
| Headache - Postdrome | 46 | 0.113 | 0.005 | 0.042–0.183 | |
| Difficulty in concentration | Prodrome - Headache | 45 | 0.072 | 0.047 | 0.005–0.138 |
| Prodrome - Postdrome | 64 | 0.198 | 0.004 | 0.060–0.320 | |
| Headache - Postdrome | 37 | 0.055 | 0.068 | 0.004–0.105 | |
| Fatigue | Prodrome - Headache | 49 | 0.112 | 0.021 | 0.021–0.202 |
| Prodrome - Postdrome | 57 | 0.075 | 0.256 | 0.056–0.206 | |
| Headache - Postdrome | 52 | 0.125 | 0.017 | 0.025–0.224 | |
| Lethargy | Prodrome - Headache | 71 | 0.397 | < 0.001 | 0.280–0.500 |
| Headache - Postdrome | 60 | 0.173 | 0.007 | 0.048–0.298 | |
| Prodrome - Postdrome | 68 | 0.195 | 0.003 | 0.060–0.330 | |
| Yawning | Prodrome – Headache | 73 | 0.297 | < 0.001 | 0.142–0.416 |
| Headache - Postdrome | 72 | 0.192 | 0.001 | 0.061–0.323 | |
| Prodrome - Postdrome | 78 | 0.237 | < 0.001 | 0.084–0.389 | |
| Neck stiffness | Prodrome - Headache | 75 | 0.505 | < 0.001 | 0.400–0.610 |
| Headache - Postdrome | 64 | 0.317 | < 0.001 | 0.416–0.218 | |
| Prodrome - Postdrome | 74 | 0.424 | < 0.001 | 0.305–0.543 | |
| Food aversion | Prodrome - Headache | 63 | 0.206 | < 0.001 | 0.108–0.304 |
| Headache - Postdrome | 61 | 0.148 | < 0.001 | 0.064–0.232 | |
| Prodrome - Postdrome | 83 | 0.058 | < 0.001 | 0.110–0.226 | |
| Food craving | Prodrome - Headache | 91 | 0.398 | < 0.001 | 0.187–0.609 |
| Headache - Postdrome | 88 | 0.207 | 0.001 | 0.009–0.405 | |
| Prodrome - Postdrome | 85 | 0.152 | 0.023 | 0.026–0.330 | |
| Frequent urination | Prodrome - Headache | 88 | 0.291 | < 0.001 | 0.103–0.479 |
| Headache - Postdrome | 81 | 0.060 | 0.358 | 0.087–0.207 | |
| Prodrome - Postdrome | 88 | 0.070 | 0.267 | 0.096–0.236 | |
| Mood disturbance | Prodrome - Headache | 61 | 0.293 | < 0.001 | 0.199–0.387 |
| Headache - Postdrome | 52 | 0.139 | 0.008 | 0.042–0.235 | |
| Prodrome – Postdrome | 75 | 0.365 | < 0.001 | 0.228–0.502 | |
| Phonophobia | Prodrome - Headache | 48 | 0.157 | < 0.001 | 0.088–0.225 |
| Headache - Postdrome | 41 | 0.093 | 0.011 | 0.032–0.153 | |
| Prodrome - Postdrome | 64 | 0.393 | < 0.001 | 0.258–0.528 | |
| Photophobia | Prodrome - Headache | 47 | 0.139 | 0.001 | 0.068–0.209 |
| Headache - Postdrome | 39 | 0.073 | 0.032 | 0.016–0.129 | |
| Prodrome - Postdrome | 72 | 0.271 | < 0.001 | 0.134–0.408 | |
| Thirst | Prodrome - Headache | 88 | 0.408 | < 0.001 | 0.228–0.588 |
| Headache - Postdrome | 86 | 0.352 | < 0.001 | 0.172–0.532 | |
| Prodrome - Postdrome | 87 | 0.186 | 0.005 | 0.006–0.378 | |
| Speech difficulty | Prodrome - Headache | 69 | 0.255 | < 0.001 | 0.156–0.354 |
| Headache - Postdrome | 68 | 0.237 | < 0.001 | 0.135–0.339 | |
| Prodrome - Postdrome | 87 | 0.244 | < 0.001 | 0.053–0.434 | |
| Nausea | Prodrome - Headache | 47 | 0.171 | < 0.001 | 0.140–0.230 |
| Headache - Postdrome | 36 | 0.080 | 0.005 | 0.069–0.229 | |
| Prodrome - Postdrome | 75 | 0.225 | < 0.001 | 0.366–0.084 | |
| Abdominal pain | Prodrome - Headache | 95 | 0.525 | < 0.001 | 0.271–0.779 |
| Headache - Postdrome | 95 | 0.498 | < 0.001 | 0.752–0.244 | |
| Prodrome - Postdrome | 98 | 0.793 | < 0.001 | 0.566–1.020 |
Abbreviations: CI Confidence interval
*Cohen’s kappa coefficients with 95% CIs. Kappa value > 0.3 (fair-good agreement) with a p < 0.05 was considered significant