Table 5.

Phenotype of patients according the presence of non-headache symptoms throughout all three phases of migraine

	Patients having at least one non-headache symptom throughout all three phases of migraine	Patients having at least one non-headache symptom in one or two phases of migraine	p value* Non-headache symptoms in all phases vs non-headache symptoms in one or two phases of migraine
N° of subjects	122 (54%)	103 (46%)	–
Median age [IQ range] [years]	45 [34–51]	47 [34–57]	0.099
Women/Men	104 (85%) – 18 (15%)	70 (68%) – 33 (32%)	0.002
Median disease duration [IQ range]	30 [16–39]	30 [20–40]	0.914
Migraine with aura/Migraine without aura	30 (25%) – 92 (75%)	18 (17%) – 85 (83%)	0.253
Median monthly headache days [IQ range]	20 [9–30]	12 [7–23]	0.001
Median monthly migraine days [IQ range]	15 [8–20]	11 [6–17]	0.056
Episodic/Chronic migraine	40 (33%) - 82 (67%)	57 (55%) – 46 (45%)	0.001
Patients taking/not taking migraine prevention	47 (39%)/ 75 (61%)	34 (33%)/ 69 (67%)	0.4
Median of preventive treatments used	3 [1–5]	3 [0–5]	0.153
Migraine with medication overuse/ Migraine without medication overuse	70 (57%) – 52 (43%)	40 (39%) – 63 (61%)	0.004
Median of monthly tablets of acute treatments [IQ range]	16 [8–30]	12 [5–20]	0.015
Median MIDAS score [IQ range]	55 [20–103]	34 [17–69]	0.004
Median HIT-6 score [IQ range]	66 [63–69]	64 [61–67]	0.002
Median NRS score [IQ range]	8 [7–9]	8 [7–9]	0.156
Median ASC score [IQ range]	5 [2–8]	4 [1–7]	0.130

^*Independent t test or Mann-Whitney test for continuous variables and the Fisher exact test for categorical variables