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. 2022 Nov 23;20:261. doi: 10.1186/s12915-022-01467-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Folate deficiency and supplementation influence mRNA translation in NSCs. a, b Schematic representation of the sucrose gradient used to segregate ribosome-free and ribosome-bound RNAs (a) and representative polysome profile (1.5μM FA, replicate 1) recorded at 254 nm, polysome fraction (portion 9 to 15) is indicated (b). c Volcano plot showing the differentially translated genes (DTGs) in comparison between LF and MF. d Volcano plot showing the differentially translated genes (DTGs) in comparison between HF and MF. e Bubble plot showing the GO terms of the DTGs: decreased translation efficiency in LF (LF vs MF down), decreased translation efficiency in HF (HF vs MF down), and increased translation efficiency in HF (HF vs MF up)