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. 2022 Nov 23;20:261. doi: 10.1186/s12915-022-01467-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Influence of folate on polysome mRNA m⁵C methylation in mouse NSCs. a Sequence frequency logo for the sequence context proximal to m⁵C sites in polysome mRNAs. b Density plot showing the distribution of m⁵C sites along mRNA transcripts (5′UTR, CDS, 3′UTR). The moving average of the percentage is shown. c Boxplot showing the methylation levels of m⁵C sites in polysome mRNAs. d Heatmap showing the methylation level of differentially methylated m⁵C sites in comparison between pMF and pLF. Two biological replicates (R1, R2) are shown. e Heatmap showing the methylation level of differentially methylated m⁵C sites in comparison between pMF and pHF. Two biological replicates (R1, R2) are shown. f GO annotation of DMS-modified mRNAs of pMF vs pLF and pMF vs pHF. Representative GO terms are shown in the table