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. Author manuscript; available in PMC: 2022 Nov 24.
Published in final edited form as: Nat Rev Mol Cell Biol. 2021 Jul 13;22(11):713–732. doi: 10.1038/s41580-021-00389-z

Figure 5 |. Skeletal Muscle Membrane Repair.

Figure 5 |

Skeletal muscle sustains small tears from normal muscle use, which are quickly repaired by cell repair machinery. a | Following a tear, calcium flows down its concentration gradient from outside the cell to inside. Cholesterol is oxidized and phosphatidyl serine changes its conformation from intracellular-facing to extracellular facing. b | Calcium, oxidized cholesterol and phospholipids activate the cellular repair machinery. Annexin proteins bind to calcium and phosphatidyl serine and form a cap that seals the are of the tear.