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. 2022 Nov 10;12:993243. doi: 10.3389/fonc.2022.993243

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Copyright © 2022 Xia, Wang, Qi, Long, Li, He, Pan, Guo and Hu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OGT is overexpressed in PC and contributes poor diagnosis in PC patients. (A) The expression level of OGT in different kinds of cancers and normal tissues from TCGA patient samples. (B) The expression level of OGT in primary prostate cancer tissues (n=497) and normal tissues(n=52) from TCGA patient samples. (C) OGT expression based on Gleason score from TCGA samples. (D) Kaplan–Meier analysis of the overall survival of patients with prostate cancer. The cut off value is 0.3. (E) The disease-free survival analysis of prostate cancer patients with high or low OGT expression from TCGA. The cut off value is 0.3. (F) Protein levels of OGT, OGA and total cellular O-GlcNAc in AR-positive (LNCaP, 22RV1) and AR-negative (PC3, DU145) PC cell lines and normal prostatic matrix immortalized cell (wpmy-1). *p < 0.05; **p < 0.01; ***p < 0.001 (Student’s t-test).