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. 2022 Nov 10;12:993243. doi: 10.3389/fonc.2022.993243

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Copyright © 2022 Xia, Wang, Qi, Long, Li, He, Pan, Guo and Hu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OSMI-4 inhibition of OGT sensitizes PC cells to docetaxel. (A) Cell survival analysis in PC3 and DU145 cells with different concentration of OSMI-4 treatment. (B) Morphological analysis of PC3 and DU145 cells treated with OSMI-4, compared with control group. (C) Cell apoptosis was analyzed by flow cytometry. (D) Treatment with OSMI-4 enhanced the expression of pro-apoptotic proteins caspase-3 and BAX, and down-regulated the O-GlcNAc levels in PC3 and DU145 cells, compared with control group. *p < 0.05; **p < 0.01; ***p < 0.001 (Student’s t-test).