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. 2022 Nov 10;12:993243. doi: 10.3389/fonc.2022.993243

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Copyright © 2022 Xia, Wang, Qi, Long, Li, He, Pan, Guo and Hu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Docetaxel treatment decreases OGT expression and increases miR-140 expression. (A) RT-qPCR results showed that miR-140 expression levels were significantly downregulated in PC cell. Values are expressed as the mean ± standard deviation. (B) MiR-140 expression levels were upregulated with the treatment of docetaxel. (C, D) OGT protein and O-GlcNAc levels were dramatically downregulated in PC3 and DU145 cells treated with different concentrations of docetaxel. *p < 0.05; **p < 0.01; ***p < 0.001 (Student’s t-test). ns, means no significance.