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. 2022 Nov 10;13:1029818. doi: 10.3389/fimmu.2022.1029818

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Copyright © 2022 Zouboulis, Coenye, He, Kabashima, Kobayashi, Niemann, Nomura, Oláh, Picardo, Quist, Sasano, Schneider, Törőcsik and Wong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Eosinophilic pustular folliculitis: An unexpected paradigm of sebaceous gland-controlled immunological reaction. Infection with human polyoma virus or Malassezia as well as the immune reconstitution inflammatory syndrome stimulate the arachidonic acid inflammatory pathway in the sebaceous gland. Prostglandins, downstreem arachidonic acid metabolites, attract eosinophils and basophils to the perisebaceous gland dermis. Indomethacin might exhibit its therapeutic effect by inhibiting cyclooxygenase levels or blocking the chemoattractant receptor homologous molecule expressed on Th2 cells and the chemokine receptor 3. HPyV, human polyoma virus; IRIS, immune reconstitution inflammatory syndrome; AA, arachidonic acid; COX, cyclo-oxygenase; PG, prostaglandin; PGDS, PGD synthase; PPARγ, peroxisome proliferator-activated receptor γ; CRTH2, chemoattractant receptor homologous molecule expressed on Th2 cells; CCR3, C-C motif chemokine receptor 3; CCL26, C-C motif chemokine ligand 26; Eos, eosinophil; Bas, basophil; ILC, innate lymphoid cell.