Table 5.
Cell viability (%) of Caco-2 cells after treatment with a single phage.
| Phage | Time (h) | Cell Viability (%) 1 | ||||
|---|---|---|---|---|---|---|
| Phage Concentration (log PFU/mL) | ||||||
| Control | 6.0 | 7.0 | 8.0 | 9.0 | ||
| vB_SenS_KP001 | 24 | 100 | 96.2 ± 4.2 | 97.1 ± 3.5 | 96.1 ± 4.4 | 98.9 ± 3.7 |
| 48 | 100 | >100 | 99.5 ± 1.7 | 98.3 ± 2.3 | 98.6 ± 4.4 | |
| 72 | 100 | >100 | >100 | 95.9 ± 3.1 * | 97.6 ± 2.9 * | |
| vB_SenS_KP005 | 24 | 100 | 96.7 ± 2.2 | 96.3 ± 1.7 | 97.0 ± 3.7 | 96.0 ± 3.8 |
| 48 | 100 | >100 | 99.2 ± 2.1 | 98.6 ± 1.6 | 96.3 ± 5.6 | |
| 72 | 100 | >100 | >100 | 99.3 ± 1.5 | 96.9 ± 2.3 * | |
| vB_SenS_WP110 | 24 | 100 | 96.0 ± 2.8 * | 95.9 ± 2.9 * | 97.0 ± 2.7 | 99.1 ± 6.5 |
| 48 | 100 | 97.7 ± 2.7 * | 99.3 ± 1.9 | 99.8 ± 1.3 | 99.2 ± 2.0 | |
| 72 | 100 | 96.4 ± 1.2 * | 95.7 ± 3.3 * | 95.3 ± 4.2 * | 98.8 ± 3.1 | |
1 All values are provided as mean ± standard deviation of triplicates. The % cell viability >100% indicates cell proliferation over the period of study; therefore, statistical analysis was performed only on those that were < 100%, and the asterisks (*) indicates the significant difference (p < 0.05) between no-phage control and treatment at the same time. The % cell viability of control was normalized at 100% for each sampling time.