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. 2022 Oct 24;11(11):1464. doi: 10.3390/antibiotics11111464
AB antibiotic-treated control
BCFA branched-chain fatty acids
C control (period)
CA cholic acid
CDI Clostridioides difficile infection
CFU colony forming units
CLI clindamycin treatment
COVID-19 coronavirus disease 19
CTRL blank control
DAPC discriminant analysis of principal components
DC distal colon
DCA deoxycholic acid
GCA glycocholic acid
LAC5 lactulose treatment with 5 g/d during the clindamycin treatment and C. difficile stabilization period
LAC5V0 lactulose treatment with 5 g/d during the vancomycin treatment and post-intervention period
LAC5V1 lactulose treatment with 5 g/d during the vancomycin treatment and post-intervention period with lactulose supplementation initiated one day before starting vancomycin treatment
LAC10 lactulose treatment with 10 g/d during the clindamycin treatment and C. difficile infection stabilization period
LAC10V0 lactulose treatment with 10 g/d during the vancomycin treatment and post-intervention period
LAC10V1 lactulose treatment with 10 g/d during the vancomycin treatment and post-intervention period with lactulose supplementation initiated one day before starting vancomycin treatment
LDA linear discriminant analysis
LEfSe linear discriminant analysis effect size
PBS phosphate buffer saline
PC proximal colon
PCA principal component analysis
PI post-intervention
RCM reinforced clostridial medium
SARS-CoV-2 severe acute respiratory syndrome coronavirus 2
SCFA short-chain fatty acids
SEM standard error of the mean
SHIME Simulator of the Human Microbial Ecosytem
Si small intestine
St stomach
TCA taurocholic acid
TCDCA taurochenodeoxycholic acid
VNC vancomycin treatment
_I first week of
_II second week of
_III third week of