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. 1999 Oct;67(10):5163–5169. doi: 10.1128/iai.67.10.5163-5169.1999

FIG. 1.

FIG. 1

Antibody titers from mice immunized with pcdna3 SERA 17-382 or pcdna3 SERA 17-110 DNA vaccines by i.m. injection. Where indicated, mice groups were coimmunized with the pCMV-s DNA plasmid, which was used as a positive control. Mice were immunized at 0, 5, and 8 weeks, and serum samples were collected at week 10. Serial dilutions were used to measure the end point-positive titers. The results presented are the averages of two separate ELISAs. The titer of each serum sample is the inverse of the largest dilution at which the substrate colorometric development is above that of a negative control. The variation in the end point-positive titers was always within one “twofold serial dilution.” Preimmune serum titers for the SERA protein were <80 in this assay.