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. 2022 Oct 25;11(11):2105. doi: 10.3390/antiox11112105

Figure 6.

Figure 6

Effect of SELENOF KO on the expression of key proteins involved in insulin signaling pathway in the liver of mice at different ages. (A) Representative Western blot bands of phosphorylated AKT (p-AKT), AKT, phosphorylated FoxO1 (p-FoxO1), FoxO1, phosphorylated GSK3β (p-GSK3β) and GSK3β. (B) Semi-quantification analysis of AKT, FoxO1 and GSK3β normalized to β-actin. (C) Semi-quantification analysis of p-AKT normalized to AKT, p-FoxO1 normalized to FoxO1, and p-GSK3β normalized to GSK3β. AKT: protein kinase B; p-AKT: phospho- AKT; FoxO1: forkhead box O1; p-FoxO1: phospho- FoxO1; GSK3β: glycogen synthase kinase-3β; p-GSK3β: phospho- GSK3β. Data were expressed as mean ± SD (n = 3). * p < 0.05, ** p < 0.01, compared with C57BL/6J mice.