Table 2.
Effects of SELENOF knockout on hepatic oxidative stress parameters in mice of different ages.
| Age (Weeks) |
Mice Types |
MDA (nmol/ mg Protein) |
GSH (nmol/mg Protein) |
GSSG (nmol/mg Protein) |
GSH/ GSSG |
GPX (U/mg Protein) |
CAT (U/mg Protein) |
T-SOD (U/mg Protein) |
|---|---|---|---|---|---|---|---|---|
| 12 | C57BL/6J | 1.8 ± 0.3 | 2.27 ± 0.25 | 0.26 ± 0.04 | 8.8 ± 1.5 | 396.8 ± 36.2 | 165.8 ± 39.1 | 311.3 ± 32.3 |
| KO | 2.2 ± 0.3 * | 1.93 ± 0.29 * | 0.35 ± 0.05 * | 5.6 ± 0.7 ** | 336.4 ± 40.8 ** | 175.6 ± 36.9 | 284.5 ± 23.9 | |
| 16 | C57BL/6J | 1.6 ± 0.3 | 2.19 ± 0.45 | 0.38 ± 0.06 | 5.8 ± 0.9 | 410.3 ± 43.8 | 169.3 ± 38.8 | 284.1 ± 22.8 |
| KO | 1.9 ± 0.4 | 2.02 ± 0.37 | 0.39 ± 0.07 | 5.3 ± 1.1 | 374.8 ± 41.1 | 182.0 ± 37.8 | 309.7 ± 31.2 | |
| 21 | C57BL/6J | 1.8 ± 0.3 | 2.60 ± 0.38 | 0.50 ± 0.06 | 5.2 ± 0.9 | 430.3 ± 90.3 | 186.9 ± 43.6 | 254.8 ± 34.6 |
| KO | 2.0 ± 0.4 | 2.30 ± 0.21 | 0.45 ± 0.05 | 5.1 ± 0.6 | 382.9 ± 41.4 | 183.6 ± 41.6 | 278.5 ±30.8 |
The data were expressed as mean ± SD (n = 8). * p < 0.05, ** p < 0.01, compared with C57BL/6J mice.