Table 2.
Antibacterial activity of sertraline (μg/mL), Cinnamomum verum EO (mg/mL), and their combination on different bacterial strains.
| Strains | MICo a | MICc b | FIC c | FICI d | R% e |
|---|---|---|---|---|---|
| Bacillus subtilis ATCC 6633 | |||||
| Sertraline | 64.0 | 4.00 | 0.06 | 0.11 | 94 |
| CEO | 1.22 | 0.06 | 0.05 | 95 | |
| Enterococcus faecalis ATCC 29212 | |||||
| Sertraline | 16.0 | 0.50 | 0.03 | 0.08 | 97 |
| CEO | 1.22 | 0.06 | 0.05 | 95 | |
| Enterococcus faecalis BN21 | |||||
| Sertraline | 32.0 | 1.00 | 0.03 | 0.13 | 97 |
| CEO | 1.22 | 0.12 | 0.10 | 90 | |
| Enterococcus faecalis BS | |||||
| Sertraline | 32.0 | 1.00 | 0.03 | 0.08 | 97 |
| CEO | 1.22 | 0.06 | 0.05 | 95 | |
| Staphylococcus aureus ATCC 25923 | |||||
| Sertraline | 16.0 | 0.50 | 0.03 | 0.13 | 97 |
| CEO | 1.22 | 0.12 | 0.10 | 90 | |
| Staphylococcus aureus ATCC 29213 | |||||
| Sertraline | 16.0 | 0.50 | 0.03 | 0.28 | 97 |
| CEO | 1.22 | 0.31 | 0.25 | 75 | |
| Staphylococcus aureus ATCC 43300 | |||||
| Sertraline | 32.0 | 1.00 | 0.03 | 0.43 | 97 |
| CEO | 1.22 | 0.49 | 0.40 | 60 | |
| Staphylococcus aureus ATCC 6538p | |||||
| Sertraline | 64.0 | 4.00 | 0.06 | 0.11 | 94 |
| CEO | 1.22 | 0.06 | 0.05 | 95 | |
| Staphylococcus aureus BS | |||||
| Sertraline | 16.0 | 1.00 | 0.06 | 0.26 | 94 |
| CEO | 1.22 | 0.24 | 0.20 | 80 | |
| Acinetobacter baumannii ATCC 19606 | |||||
| Sertraline | 16.0 | 0.50 | 0.03 | 0.08 | 97 |
| CEO | 1.22 | 0.06 | 0.20 | 80 | |
| Corynebacterium striatum RM | |||||
| Sertraline | 32.0 | 1.00 | 0.03 | 0.08 | 97 |
| CEO | 2.44 | 0.13 | 0.20 | 95 | |
| Escherichia coli ATCC 25922 | |||||
| Sertraline | 16.0 | 0.50 | 0.03 | 0.23 | 97 |
| CEO | 4.88 | 0.98 | 0.20 | 80 | |
| Escherichia coli ESBL | |||||
| Sertraline | 32.0 | 1.00 | 0.03 | 0.43 | 97 |
| CEO | 4.88 | 1.95 | 0.40 | 60 | |
| Klebsiella pneumoniae ATCC 13883 | |||||
| Sertraline | 33.0 | 1.03 | 0.13 | 0.53 | 97 |
| CEO | 4.88 | 1.95 | 0.40 | 60 | |
| Pseudomonas aeruginosa ATCC 27853 | |||||
| Sertraline | 64.0 | 8.00 | 0.06 | 0.11 | 87 |
| CEO | 4.88 | 0.24 | 0.05 | 95 |
All the MIC (minimal inhibitory concentration) values for sertraline and CEO are reported in μg/mL and mg/mL, respectively. a MICo: MIC of single component tested alone; b MICc: MIC of each component in the association at the most effective inhibition growth; c FIC: Fractional inhibitory concentrations is determined by the ratio MICc/MICo; d FICI (fractional inhibitory concentration index): FIC of sertraline + FIC of C EO; e R% represents the percentage reduction in the amount of each associated component, compared to each single component. FIC and FICI are reported as means of three replicates.