Figure 10.

Steady state probability curves as a function of voltage for cells containing various channel types in four different experiments. The coexpression data and homomeric data for model fitting was taken from (A,B) Miceli et al. (2013) and (C,D) Miceli et al. (2015). The steady state probability curves presented here are for homomeric K_v7.2 (4:0) and K_v7.2 mutant (0:4) channels, heteromeric assembly of K_v7.2 and K_v7.2 mutant subunits (3:1, 2:2, 1:3), the model output of a random assembly of K_v7.2 and K_v7.2 mutant subunits expressed in 50:50 ratio (rand), the data output of a 50:50 expression of K_v7.2 and mutant K_v7.2 subunits (coexpression data), and a model output of an equal split between only homomeric channels (50:50). Curve color and type are shown in the legends. Homomeric channels and their related heteromers being looked at are also detailed in figure titles.