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. 2022 Nov 10;16:1036813. doi: 10.3389/fncel.2022.1036813

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Copyright © 2022 McGahan and Keener.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Steady state probability curves as a function of voltage for cells containing various channel types. The coexpression data and homomeric data for model fitting was taken from Mani et al. (2016). The steady state probability curves presented here are for homomeric K_v7.4 (4:0) and K_v7.5 (0:4) channels, heteromeric K_v7.4/7.5 channels (3:1, 2:2, 1:3), the model output of a random assembly of K_v7.4 and K_v7.5 subunits expressed in 50:50 ratio (rand), the data output of a 50:50 expression of K_v7.4 and K_v7.5 subunits (coexpression data), and a model output of an equal split between only homomeric channels (50:50). Curve color and type are shown in the legend. Homomeric channels and their related heteromers being looked at are also detailed in figure title.