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. 2022 Oct 24;11(11):2092. doi: 10.3390/antiox11112092

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The effects of DOTAP and cholesterol ratios within liposomal composition on size, polydispersity, charge and STS entrapment. Liposomes formulated with DSPE-PEG and varying ratios of PC, DOTAP and cholesterol were prepared by the extrusion method. Sodium thiosulphate (STS) was dispersed within the buffer (25 mg/mL). (A) Liposome size distribution and (B) polydispersity was determined by DLS, (C) zeta potential was determined by photon correlation spectroscopy using a Zetaplus and (D) entrapment efficiency determined by HPLC-UV. Data represents mean ± SD. (n = 3) independent batches. Statistical differences: * p < 0.05 and **** p < 0.0001.