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. 2022 Nov 16;11(11):2258. doi: 10.3390/antiox11112258

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Representative photomicrograph of wound tissue on day 7 and 14 (H&E (A1–A3) and Masson trichrome stains (B1–B3) × 200 and 400). Untreated group (A1) showing the wide wound area (circle), and the underlying sloughed granulation tissue showing congested blood capillaries, neovascularization, and inflammatory cells infiltration of mainly neutrophils (arrow in the inset). (B1) Showing the wound bed is loaded with a dense granulation tissue composed of compact disorganized collagen (stars). Mebo-treated group (A2) showing creeping of epidermal cells closing the wound (yellow arrow), granulation tissue (stars), and inflammatory cellular infiltration of mainly macrophages (black arrows). (B2) Showing well-formed dermal coarse and wavy collagen bundles (stars). Launaea extract-treated group (A3) showing normal epidermis with newly formed hair follicles (HF). (B3) Showing collagen bundles in the papillary layer, which appear as fine interlacing bundles (PL), and in the reticular layer, which appear as coarse wavy bundles (RL), hair follicles, and sebaceous glands (HF).