Figure 1.

Proliferating TAMs in human cancers. Sections are from human pleural mesothelioma (A), lung adenosquamous carcinoma (B), serous ovarian carcinoma (C) and transitional bladder carcinoma (D–F) and stained as labelled. A variable fraction of CD163⁺ TAMs co-express the proliferation marker ki-67 as demonstrated by double immunostaining (A–C,E); a minor fraction of TAMs also co-express nuclear Myc and Cyclin D1 as revealed by sequential double immunostains (D–F). Images are obtained from 40× digitalized slides and resized using Adobe Photoshop. Scale bar (A–C), 44 μM; (D–F), 33 μM.