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DCs efficiently cross-present the A2L epitope only when displayed by ADD RGD. Purified panDCs were incubated with ADD Ø, ADD KGE/RGD +/− RBD, Peptide MelA and Peptide MelA + TLR-L for 1 h and cocultured 20 h with MelA26–35 specific CD8+ T cells. IFNg secretion was then evaluated by CBA. T cells were also cultured alone (−) or with PMA/iono (+) (n = 2 donors).
