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. 2022 Nov 15;12(11):1690. doi: 10.3390/biom12111690

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Data of the discovery cohort in a double logarithmic FLCκ quotient diagram. The bold line shows Qlim, the dashed line shows the Qmean. The bottom dashed line shows the Qlow. 302 samples (44%) showed an intrathecal FLCκ synthesis (IF FLCκ > 0) of which 60 patient samples showed no other signs of a humoral immune response (negative OCB, IF IgG/IF IgA/IF IgM < 0). 245 patient samples presented signs of an intrathecal inflammation (positive OCB () or Ig synthesis in the corresponding quotient diagram ()) of which 4 lacked an intrathecal FLCκ synthesis (IF FLCκ < 0). FLCκ: free light chains kappa, Q: quotient, Alb: albumin.

Inline graphic — Data of the discovery cohort in a double logarithmic FLCκ quotient diagram. The bold line shows Qlim, the dashed line shows the Qmean. The bottom dashed line shows the Qlow. 302 samples (44%) showed an intrathecal FLCκ synthesis (IF FLCκ > 0) of which 60 patient samples showed no other signs of a humoral immune response (negative OCB, IF IgG/IF IgA/IF IgM < 0). 245 patient samples presented signs of an intrathecal inflammation (positive OCB () or Ig synthesis in the corresponding quotient diagram ()) of which 4 lacked an intrathecal FLCκ synthesis (IF FLCκ < 0). FLCκ: free light chains kappa, Q: quotient, Alb: albumin.