Table 1.
Continuous data are expressed as median (first; third quartiles); nominal data are given as percentages, Ig-synthesis are given as quantity and percent. CSF cerebrospinal fluid, OCB oligoclonal bands, CC cell count (leukocytes), Ig immunoglobulin, QIgG/A/M immunoglobulin G/A/M quotient, QAlb albumin quotient, FLCκ free light chains kappa.
| Discovery Cohort (n = 679) | Validation Cohort (n = 278) | |
|---|---|---|
| Age (y) | 52 (36; 65) | 56 (41; 69) |
| QAlb | 6.4 (4.7; 9.1) | 6.7 (5.1; 9.4) |
| QIgG | 3.6 (2.5; 5.1) | 3.1 (2.3; 4.5) |
| QIgA | 1.9 (1.2; 2.9) | 1.7 (1.2; 2.7) |
| QIgM | 0.4 (0.2; 0.8) | 0.3 (0.2; 0.7) |
| One-class Ig immune response | ||
| IgG-synthesis; n (%) | 71 (10) | 12 (4) |
| IgA-synthesis; n (%) | 10 (1.4) | 0 |
| IgM-synthesis; n (%) | 19 (2.7) | 1 (0.3) |
| Two-class Ig immune response | ||
| IgG/M-synthesis; n (%) | 31 (4.5) | 6 (2) |
| IgA/M-synthesis; n (%) | 12 (1.8) | 1 (0.3) |
| IgG/A-synthesis; n (%) | 9 (1.3) | 1 (0.3) |
| Three-class Ig immune response | 4 (0.05) | 2 (0.7) |
| Artificial blood Contamination, n (%) | 18 (2.3) | 1 (0.3) |
| CSF specific OCB; n (%) | 204 (30) | 31 (11) |
| CC/µL | 1 (1; 4) | 1 (1; 2) |
| FLCκ IF > 0%; n (%) | 302 (44) | 67 (24) |
| FLCκ serum (mg/L) | 13.1 (10.2; 18) | 13.1 (9.81; 17.97) |
| FLCκ CSF (mg/L) | 0.363 (0.189; 1.63) | 0.23 (0.12; 0.48) |
| QFLCκ | 21.5 (12.04; 111.38) | 15.21 (10.29; 26.28) |