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. 2022 Oct 29;12(11):1595. doi: 10.3390/biom12111595

Figure 2.

Figure 2

Transport of nuclear-encoded mitochondrial transcripts in neurons. Motor proteins actively transport RNA granules, mitochondria and Rab5-positive early endosomes as well as Rab7- and LAMP1-positive endolysosomes along axons. In this way, nuclear-encoded mitochondrial transcripts that are either part of RNA granules or tethered to the organelles reach distal parts of the neurons allowing for local translation. (A) The mitochondrial laminb2 and bclw transcripts are transported in RNA granules via binding to their RBP SFPQ. Cox7c and Pink1 mRNA are tethered to mitochondria. The tethering complex for Pink1 mRNA is composed of SYNJ2BP and SYNJ2. (B) Several mRNAs are transported with early endosomes. The FERRY complex localizes to early endosomes and interacts both with the translation machinery and mRNAs that are enriched for nuclear-encoded mitochondrial genes. (C) Endolysosomes transport G3BP1-containing RNA granules using ANXA11 as a tether.