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. 2022 Nov 22;99(21):e2395–e2405. doi: 10.1212/WNL.0000000000201200

Figure 4. Relationship Between Brain Dynamics and Clinical Features in the ALS Group in the Delta (A and B) and the Theta (C and D) Frequency Bands.

Figure 4

(A) Positive correlation between the number of unique avalanche patterns and the ALSFRS-R (R = 0.37, p = 0.019) and (B) negative correlation between the number of patterns and the King's clinical staging system (R = −0.51, p = 0.002) in the delta band; (C) Positive correlation between the number of unique avalanche patterns and the ALSFRS-R (R = 0.40, p = 0.015) and (D) negative correlation between the number of patterns and the King's clinical staging system (R = −0.53, p = 0.002) in the theta band. The Spearman correlation coefficient was used, and the results were corrected by false discovery rate (FDR) correction. Significance p-values: *p < 0.05, **p < 0.01. The figure was made using Matlab 2019a. ALS = amyotrophic lateral sclerosis.