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Anti-angiogenic effects of AgNPs in vivo using a matrigel plug model with BRECs. Matrigel plugs containing BRECs with and without 50 ng/mL VEGF were implanted into mice for 7 days. Angiogenesis occurred in mice treated with VEGF alone (A). The AgNPs inhibited the VEGF-induced angiogenesis in mice implanted with matrigel plugs containing BRECs with 50 ng/mL VEGF and 500 nM AgNPs after 7 days (B). Adapted from [99].
