Table 7.

AgNPs-based products approved by FDA for clinical trials.

Status	Study Title	ClinicalTrials.gov Identifier	AgNPs Formulation	Condition	Participants	Administration Route	Phase
Active, recruiting	Colloidal silver, treatment for COVID-19	NCT04978025	AgNPs	Severe acute respiratory syndrome	50	Oral and inhalation	N/A
Completed	Topical application of silver nanoparticles and oral pathogens in ill patients	NCT02761525	12 ppm of AgNPs- innocuous gel	Critical illness	50	Oral mucosa	N/A
	Silver nanoparticles in multi-drug-resistant bacteria	NCT04431440	AgNPs	Methicillin and vancomycin-resistant S. aureus	150	Tested on clinical isolates	N/A
	Nano-silver fluoride to prevent dental biofilms growth	NCT01950546	5% nanosilver fluoride (390 mg/mL 9 nm AgNPs, 21 mg/mL chitosan, 22 mg/mL NaF)	Dental caries	30	Applied on cervical vestibular surfaces of incisors and canines	1
	The anti-bacterial effect of nano-silver fluoride on primary teeth	NCT05221749	Nano-silver fluoride	Dental caries in children (1–12 years old)	50	Oral	3
	Evaluation of silver nanoparticles for the prevention of COVID-19	NCT04894409	ARGOVIT® AgNPs (Mouthwash and nose rinse)	COVID-2019	231	Mouthwash and nose rinse	N/A
	Assessment of postoperative pain after using various intracanal medications in patients with necrotic pulp	NCT03692286	AgNPs and calcium hydroxide vs. AgNPs in gel form	Necrotic pulp (postoperative pain)	30	Intracanal medication	4
	Effect of thyme and carvacrol nanoparticles on aspergillus fumigatus isolate from intensive care patients	NCT04431804	AgNPs	Aspergillosis	210	Aspergillus isolates	N/A
	Evaluation of diabetic foot wound healing using hydrogel and nano silver-based dressing vs. traditional dressing	NCT04834245	Hydrogel and nano silver-based dressing	Diabetic wounds	30	Topical wound dressing	N/A
	Comparison of central venous catheters (CVC) with silver nanoparticles versus conventional catheters	NCT00337714	CVC impregnated with AgNPs (AgTive®)	CVC related infections	472	Cannulation	4
Unknown	Topical silver nanoparticles for microbial activity	NCT03752424	AgNPs-cream	Fungal infection (Tinea pedis, Capitis and Versicolor)	30	Topical	1
	Research on the key technology of burn wound treatment	NCT03279549	Nano-silver ion gel and dressings	Burns	200	Topical	N/A
	Addition of silver nanoparticles to an orthodontic primer in preventing enamel demineralisation adjacent brackets	NCT02400957	AgNPs incorporated into the primer orthodontic Transbond XT	Tooth demineralisation	40	Dental application	3
	Fluor varnish with silver nanoparticles for dental remineralisation in patients with Trisomy 21	NCT01975545	25% of 50 nm AgNPs in fluor varnish	Dental remineralisation in patients with Down syndrome	20	Oral varnish	2
	Efficacy of silver nanoparticle gel versus a common anti-bacterial hand gel	NCT00659204	Nano-silver gel (SilvaSorb® gel)	Healthy	40	Topical on hands	3