Table 4.

OA regulators expressed by at least 1% of indicated cell types and targeted by first quartile EV-miRNAs.

	CHO	SYN	HLA-DR+	T CELL	% WEIGHT	MAIN miRNA
CYTOKINES
TNF		X	X		2.05	hsa-miR-125-5p (1.23%)
IL6		X	X		0.19	hsa-miR-146a-5p (0.19%)
IL1B		X	X		0.88	hsa-miR-21-5p (0.88%)
IL1A		X	X		5.58	hsa-miR-191-5p (5.58%)
CXCL12		X	X		0.97	hsa-miR-221-3p (0.57%)
CCL5		X	X	X	1.51	hsa-miR-214-3p (1.32%)
IL11	X	X	X		0.61	hsa-miR-30c-5p (0.61%)
GROWTH FACTORS
TGFB1	X	X	X	X	19.24	hsa-miR-24-3p (13.17%)
IGF1		X	X		0.87	hsa-miR-29a-3p (0.64%)
FGF2	X	X			0.97	hsa-miR-16-5p (0.82%)
BMP2	X	X	X		1.65	hsa-miR-106a-5p (0.83%)
VEGFA	X	X	X		6.22	hsa-miR-145-5p (1.25%)
HGF		X	X		1.05	hsa-miR-16-5p (0.82%)
ANGPT2		X	X		2.48	hsa-miR-145-5p (1.25%)
CTGF	X	X	X		1.86	hsa-miR-145-5p (1.25%)
KITLG	X	X	X		3.47	hsa-miR-320a-3p (3.47%)
TGFB2	X	X	X		2.13	hsa-miR-145-5p (1.25%)
INHBB		X			0.17	hsa-miR-34a-5p (0.17%)
IGF2	X	X			1.5	hsa-miR-125b-5p (1.23%)
BDNF		X			1.22	hsa-miR-16-5p (0.82%)
PROTEASES
ADAM12	X	X			0.64	hsa-miR-29a-3p (0.64%)
ADAM17	X	X	X		1.25	hsa-miR-145-5p (1.25%)
ADAMTS9		X			0.64	hsa-miR-29a-3p (0.64%)
MMP1		X			8.84	hsa-miR-222-3p (7.59%)
MMP2	X	X			3.26	hsa-miR-125b-5p (1.23%)
MMP9		X	X		0.4	hsa-miR-132-3p (0.40%)
MMP13					1.23	hsa-miR-125b-5p (1.23%)
MMP14	X	X			14.42	hsa-miR-24-3p (13.17%)
PLAU		X	X		8.39	hsa-miR-193b-3p (8.39%)
PLAT	X	X			0.88	hsa-miR-21-5p (0.88%)
APC	X	X			2.06	hsa-miR-125b-5p (1.23%)
TIMP2	X	X			1.26	hsa-miR-106a-5p (0.83%)
TIMP3	X	X			9.86	hsa-miR-222-3p (7.59%)

CHO stands for chondrocytes, SYN for synoviocytes.