Table 4.
OA regulators expressed by at least 1% of indicated cell types and targeted by first quartile EV-miRNAs.
CHO | SYN | HLA-DR+ | T CELL | % WEIGHT | MAIN miRNA | |
---|---|---|---|---|---|---|
CYTOKINES | ||||||
TNF | X | X | 2.05 | hsa-miR-125-5p (1.23%) | ||
IL6 | X | X | 0.19 | hsa-miR-146a-5p (0.19%) | ||
IL1B | X | X | 0.88 | hsa-miR-21-5p (0.88%) | ||
IL1A | X | X | 5.58 | hsa-miR-191-5p (5.58%) | ||
CXCL12 | X | X | 0.97 | hsa-miR-221-3p (0.57%) | ||
CCL5 | X | X | X | 1.51 | hsa-miR-214-3p (1.32%) | |
IL11 | X | X | X | 0.61 | hsa-miR-30c-5p (0.61%) | |
GROWTH
FACTORS |
||||||
TGFB1 | X | X | X | X | 19.24 | hsa-miR-24-3p (13.17%) |
IGF1 | X | X | 0.87 | hsa-miR-29a-3p (0.64%) | ||
FGF2 | X | X | 0.97 | hsa-miR-16-5p (0.82%) | ||
BMP2 | X | X | X | 1.65 | hsa-miR-106a-5p (0.83%) | |
VEGFA | X | X | X | 6.22 | hsa-miR-145-5p (1.25%) | |
HGF | X | X | 1.05 | hsa-miR-16-5p (0.82%) | ||
ANGPT2 | X | X | 2.48 | hsa-miR-145-5p (1.25%) | ||
CTGF | X | X | X | 1.86 | hsa-miR-145-5p (1.25%) | |
KITLG | X | X | X | 3.47 | hsa-miR-320a-3p (3.47%) | |
TGFB2 | X | X | X | 2.13 | hsa-miR-145-5p (1.25%) | |
INHBB | X | 0.17 | hsa-miR-34a-5p (0.17%) | |||
IGF2 | X | X | 1.5 | hsa-miR-125b-5p (1.23%) | ||
BDNF | X | 1.22 | hsa-miR-16-5p (0.82%) | |||
PROTEASES | ||||||
ADAM12 | X | X | 0.64 | hsa-miR-29a-3p (0.64%) | ||
ADAM17 | X | X | X | 1.25 | hsa-miR-145-5p (1.25%) | |
ADAMTS9 | X | 0.64 | hsa-miR-29a-3p (0.64%) | |||
MMP1 | X | 8.84 | hsa-miR-222-3p (7.59%) | |||
MMP2 | X | X | 3.26 | hsa-miR-125b-5p (1.23%) | ||
MMP9 | X | X | 0.4 | hsa-miR-132-3p (0.40%) | ||
MMP13 | 1.23 | hsa-miR-125b-5p (1.23%) | ||||
MMP14 | X | X | 14.42 | hsa-miR-24-3p (13.17%) | ||
PLAU | X | X | 8.39 | hsa-miR-193b-3p (8.39%) | ||
PLAT | X | X | 0.88 | hsa-miR-21-5p (0.88%) | ||
APC | X | X | 2.06 | hsa-miR-125b-5p (1.23%) | ||
TIMP2 | X | X | 1.26 | hsa-miR-106a-5p (0.83%) | ||
TIMP3 | X | X | 9.86 | hsa-miR-222-3p (7.59%) |
CHO stands for chondrocytes, SYN for synoviocytes.