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. 2022 Oct 27;10(11):2721. doi: 10.3390/biomedicines10112721

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Hippocampal MRI parameter maps. (A) Comparison between rats with sham-operation or traumatic brain injury (TBI). (B) Comparison between injured rats without (TBI−) or with (TBI+) epilepsy. (C) Comparison between injured rats without (CI−) or with (CI+) cognitive impairment. The mean and standard deviation (SD) of each MRI parameter map were estimated at different positions along the septotemporal axis of the hippocampus for each animal (0 refers to the temporal pole). The plots show the group averages of the animal means (line) and SDs (shaded area). Abbreviations: FA, fractional anisotropy; MD, mean diffusivity; RD, radial diffusivity. Statistical significance: The Mann–Whitney U-test was used to test for differences between the groups in mean and SD of each parameter at each position along the hippocampal axis. A statistically significant difference after controlling for multiple comparisons is indicated with *.

Hippocampal MRI parameter maps. (A) Comparison between rats with sham-operation or traumatic brain injury (TBI). (B) Comparison between injured rats without (TBI−) or with (TBI+) epilepsy. (C) Comparison between injured rats without (CI−) or with (CI+) cognitive impairment. The mean and standard deviation (SD) of each MRI parameter map were estimated at different positions along the septotemporal axis of the hippocampus for each animal (0 refers to the temporal pole). The plots show the group averages of the animal means (line) and SDs (shaded area). Abbreviations: FA, fractional anisotropy; MD, mean diffusivity; RD, radial diffusivity. Statistical significance: The Mann–Whitney U-test was used to test for differences between the groups in mean and SD of each parameter at each position along the hippocampal axis. A statistically significant difference after controlling for multiple comparisons is indicated with *.