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. 2022 Nov 2;10(11):2784. doi: 10.3390/biomedicines10112784

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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ROS levels during wound healing and metastasis. (A) ROS level during normal wound healing. After injury, high levels of ROS (red) are produced and then decreased to low level (green) over time to restore tissue integrity. (B) ROS level during chronic wound healing. After injury, high levels of ROS (red) are produced and failed to be reduced inducing non-healing wound. (C) ROS level during tumor progression. In tumor, ROS are produced in an intermediate level (orange). When ROS level increased, tumor progression is promoted leading to metastasis.