Table 1.

Clinicopathological characteristics of platinum refractory HPV ² negative R/M HNSCC and previous treatment.

Characteristics	All Patients N 10
Age (years) Median age (range)	66 (46–76)
Gender Male Female	8 2
Baseline PS 1 0 1	2 8
Risk factors Smoking history (SH) Alcohol abuse (AA)	8 3
Tumor Location Oral cavity Oropharynx Larynx	4 1 5
Histology Squamous cell carcinoma	10
Grading 2 3	4 6
HPV 2 Positive Negative	0 10
Only recurrent disease Metastatic site ≥ 1 Previous I line (extreme)	1 9 10

¹ PS: ECOG performance status at baseline, before nivolumab treatment. ² HPV: human papilloma virus.