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. 2022 Oct 26;12(11):1567. doi: 10.3390/biom12111567

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Levels of gut steroids in the colon of the control (black bar) and finasteride-treated (white bar) rats: effect after treatment. Pregnenolone (PREG, (A)), progesterone (PROG, (B)), dihydroprogesterone (DHP, (C)), allopregnanolone (ALLO, (D)), isoallopregnanolone (ISOALLO, (E)), dehydroepiandrosterone (DHEA, (F)), testosterone (T, (G)), dihydrotestosterone (DHT, (H)), 5α-androstane-3α, 17β-diol (3α-diol, (I)) and 17beta-estradiol (17β-E, J). Data are expressed as pg/mg ± SEM, n = 6 for each group. Unpaired Student’s t-test analysis: * p < 0.05, ** p < 0.01 vs. control rat colon. U.d.l. = under the detection limit. Detection limits were 0.05 pg/mg for dehydroepiandrosterone, 0.1 pg/mg for isoallopregnanolone and 0.02 pg/mg for 17β-Estradiol.