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. 2022 Oct 26;10(11):2710. doi: 10.3390/biomedicines10112710

Table 1.

Demographic and clinical manifestations of patients with retinal microvasculopathy.

Author, Month, Year Study Design Location Country Age, Gender Total Eyes Diagnosis COVID Status Biochemistry Comorbidity
Marinho PM et al [14],
May, 2020
Case series Brazil Range 25–70 11 Cotton wool spot and retinal microhemorrhages (n 4) RT-PCR+ (n 9)
Antibody+ (n 2)
NA NA
Invernizzi A, et al [16],
Oct, 2020
Case series Italy 50 (range 23–82) 54 Cotton wool spot (7.4%)
Retinal hemorrhages (9.25%)
Dilated veins
(11.1%)
Tortuous veins (12.9%)
RT-PCR+ PT (ratio) 1.19, PTT
(ratio) 1.16
Fibrinogen (mg/dL)
550.2
CRP (mg/L) 26.2
Ferritin (mg/L) 662
LDH (U/L) 270.9
Hypertension, diabetes, dyslipidemia,
stroke
Aydemir E, et al [18],
July, 2021
Case control series Turkey Mean 38 46 cases Dilated arteries and veins RT-PCR+ NA NA
Pereira LA, et al [19],
May 2020
Case series Brazil Median 62.5 18 Cotton wool spot (16.7%)
Retinal flame-shaped hemorrhages
(22.2%)
RT-PCR+
ICU (94.4%)
NA Hypertension, diabetes

RT-PCR: real time polymerase chain reaction; IUC: intensive unit care; NA: not applicable; CRP: C-reactive protein; LDH: lactate dehydrogenase.