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. 2022 Oct 23;12(11):1546. doi: 10.3390/biom12111546

Figure 3.

Figure 3

TAX prevents the ISO-induced histopathological damage in the heart. Images of the microscopic field of cardiac sections from (A) control and (B) TAX-treated mice showing normal branched connected myocardial fibers with a normal central nucleus (arrowheads); (C) ISO-treated animals demonstrating marked myolysis (white arrowhead), marked nuclear pyknosis, and infiltration of mononuclear inflammatory cells (black arrowhead); (D) ISO-injected mice pre-treated with 25 mg TAX demonstrating a reduction in myocardial degeneration of muscle fibers (white arrowhead) and mild infiltration of mononuclear inflammatory cells (black arrowhead); and (E) ISO-injected mice pre-treated with 50 mg TAX demonstrating a noticeable reduction in myocardial degeneration and with mild curving of cardiac muscle fibers (arrowhead) (H&E, X200, Scale bar = 50 µm).