Table 1.

Hepatic and extrahepatic expression profiles of human CYP3A4 and CYP3A5.

	CYP3A4		CYP3A5
	Internal
Liver	Abundance 68–155 pmol/mg RNA sequencing (RNA-seq): very high expression Microarray and RNA-seq: over-expressed	[23,36,37,38,39,40,41,42] [43] [44]	Abundance 2–5 (CYP3A5*3 allele) or 60–291 (CYP3A5*1 allele) pmol/mg Microarray and RNA-seq: overex-pressed RNA-seq: high expression	[45] [44] [43]
Small intestine	RNA detected by real-time PCR; protein detected; enzyme activity detected	[46,47,48]	RNA detected by real-time PCR; protein detected; enzyme activity detected	[41,47,48]
	Microarray and RNA-seq: overexpressed	[44]	Microarray and RNA-seq: overexpressed	[44]
	RNA-seq: very high expression	[43]	RNA-seq: high expression	[43]
Duodenum	RNA-seq: very high expression	[43]	RNA-seq: high expression	[43]
Colon	Microarray and RNA-seq: detected RNA-seq: low expression	[44] [43]	Microarray and RNA-seq: detected RNA-seq: high expression	[44] [43]
Esophagus	RNA-seq detected RNA-seq: low expression	[44] [43]	RNA-seq detected RNA-seq: moderate expression	[44] [43]
Stomach	RNA-seq detected RNA-seq: low expression	[44] [43]	RNA-seq detected RNA-seq: high expression	[44] [43]
Gall bladder	RNA-seq: low expression	[43]	RNA-seq: high expression	[43]
Kidney	RNA detected by real-time PCR; protein detected; enzyme activity detected	[43,44,46,49]	RNA detected by real-time PCR; protein detected; enzyme activity detected	[46,49]
	Microarray and RNA-seq: detected	[44]	Microarray and RNA-seq: detected	[44]
	RNA-seq: low expression	[43]	RNA-seq: moderate expression	[43]
Lung	RNA detected by real-time PCR	[46]	RNA detected by real-time PCR	[46]
	Microarray and RNA-seq: detected	[44]	Microarray and RNA-seq: detected	[44]
	RNA-seq: low expression	[43]	RNA-seq: moderate expression	[43]
Adipocyte, adipose tissue	Microarray and RNA-seq: detected RNA-seq: low expression	[44] [43]	Microarray and RNA-seq: detected RNA-seq: low expression	[44] [43]
Spleen	RNA-seq detected RNA-seq: extremely low expression	[44] [43]	RNA-seq detected RNA-seq: low expression	[44] [43]
Bladder	RNA-seq: low expression	[43]	RNA-seq: moderate expression	[43]
Secretory
Pancreas	RNA-seq detected RNA-seq: low expression	[44] [43]	RNA-seq: moderate expression	[43]
Adrenal gland	RNA detected by real-time PCR	[46]	RNA detected by real-time PCR	[46]
	Microarray and RNA-seq: detected	[44]	Microarray and RNA-seq: detected	[44]
	RNA-seq: moderate expression	[43]	RNA-seq: moderate expression	[43]
Pituitary	RNA-seq detected	[44]	RNA-seq detected	[44]
Thyroid gland	Microarray and RNA-seq: detected RNA-seq: extremely low expression	[44] [43]	Microarray and RNA-seq: detected RNA-seq: low expression	[44] [43]
Salivary gland	Microarray and RNA-seq: detected RNA-seq: extremely low expression	[44] [43]	Microarray and RNA-seq: detected RNA-seq: low expression	[44] [43]
Breast	RNA-seq detected	[44]	RNA-seq detected	[44]
Skin/keratinocytes	RNA detected by real-time PCR Microarray and RNA-seq: detected RNA-seq: low expression	[50] [44] [43]	Microarray and RNA-seq: detected RNA-seq: high expression	[44] [43]
Nervous
Brain (cortex)	Not detectable	[51]	RNA detected by real-time PCR; protein detected	[52,53]
	RNA-seq detected	[44]	Microarray and RNA-seq: detected	[44]
	RNA-seq: extremely low expression	[43]	RNA-seq: low expression	[43]
Cerebellum	Microarray and RNA-seq: detected	[44]	Microarray and RNA-seq: detected	[44]
Retina	Microarray: detected	[44]	Microarray: detected	[44]
Spinal cord	Microarray and RNA-seq: detected	[44]	Microarray and RNA-seq: detected	[44]
Tibial nerve	RNA-seq detected	[44]	RNA-seq detected	[44]
Muscle
Heart	Not detectable	[54]	Not detectable	[54]
	Microarray and RNA-seq: detected	[44]	Microarray and RNA-seq: detected	[44]
	RNA-seq: extremely low expression	[43]	RNA-seq: low expression	[43]
Artery	RNA-seq detected	[44]	RNA-seq detected	[44]
Smooth muscle	Microarray: detected	[44]	Microarray: detected	[44]
Skeletal muscle	Microarray and RNA-seq: detected	[44]	Microarray and RNA-seq: detected	[44]
Reproductive
Ovary	Not quantifiable	[43]	RNA detected by real-time PCR	[46]
	Microarray and RNA-seq: detected	[44]	Microarray and RNA-seq: detected	[44]
	RNA-seq: low expression	[43]	RNA-seq: low expression	[43]
Uterus	Microarray and RNA-seq: detected	[44]	Microarray and RNA-seq: detected	[44]
Endometrium	RNA-seq: low expression	[43]	RNA-seq: moderate expression	[43]
Placenta	Not detectable	[46]	RNA detected by real-time PCR	[46]
	Microarray and RNA-seq: detected	[44]	Microarray: detected	[44]
	RNA-seq: not detectable	[43]	RNA-seq: low expression	[43]
Prostate	RNA detected by real-time PCR	[46]	RNA detected by real-time PCR	[46]
	Microarray and RNA-seq: detected	[44]	Microarray and RNA-seq: detected	[44]
	RNA-seq: low expression	[43]	RNA-seq: moderate expression	[43]
Testis	RNA detected by real-time PCR	[46]	RNA detected by real-time PCR	[46]
	Microarray and RNA-seq: detected	[44]	Microarray and RNA-seq: detected	[44]
	RNA-seq: low expression	[43]	RNA-seq: low expression	[43]
Immune
Lymph node	Microarray: detected RNA-seq: low expression	[44] [43]	Microarray and RNA-seq: detected RNA-seq: low expression	[44] [43]
Bone marrow	Microarray: detected RNA-seq: extremely low expression	[44] [43]	Microarray: detected RNA-seq: low expression	[44] [43]
Whole blood	Microarray and RNA-seq: detected	[44]	Microarray and RNA-seq: detected	[44]
White blood cells	Not detected	[44]	RNA-seq: detected	[44]
Thymus	Microarray: detected	[44]	Microarray: detected	[44]
Appendix	RNA-seq: low expression	[43]	RNA-seq: moderate expression	[43]